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Title: Use of Discrete-time Survival Analysis for Modeling Multivariate ACE Models of Fertility Precursors from the Children of the NLSY
Resulting in 1 citation.
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Bard, David E. Rodgers, Joseph Lee |
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Use of Discrete-time Survival Analysis for Modeling Multivariate ACE Models of Fertility Precursors from the Children of the NLSY Presented: Storrs, CT, Behavior Genetics Association Annual Conference, 36th Annual, June 2006. Also: http://www.bga.org//meetings/2006/Abstracts.pdf Cohort(s): Children of the NLSY79, NLSY79, NLSY79 Young Adult Publisher: Behavior Genetics Association Keyword(s): Age at First Intercourse; Age at Menarche/First Menstruation; Fertility; Genetics; Intergenerational Patterns/Transmission; Siblings Permission to reprint the abstract has not been received from the publisher. Substantial evidence now exists that variables measuring or correlated with fertility outcomes have a heritable component. In this study, we define a series of age-sequenced fertility precursors and fit a multivariate ACE model to responses from the children (now adolescents and young adults) born to mothers of the original National Longitudinal Survey of Youth (NLSY) cohort. Three age-related precursors were considered: age at 1st menstruation, 1st dating experience, and 1st sexual intercourse. Univariate and multivariate models were in general agreement indicating strong heritability for each precursor, little to no shared environmental influences, and small to moderate nonshared influences. Genetic components in the MV model accounted for 47%, 71%, and 54% of the precursor variations, respectively. Methodologically, this study also explored the use of MV random effect discrete-time survival analyses of the precursor data. These models also incorporated an additional precursor (age at 1st marriage) and a fertility outcome (age at 1st childbirth). Results from these 5-variable discrete-time survival models are compared to biased effects from models that excluded censored cases. |
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Bibliography Citation
Bard, David E. and Joseph Lee Rodgers. "Use of Discrete-time Survival Analysis for Modeling Multivariate ACE Models of Fertility Precursors from the Children of the NLSY." Presented: Storrs, CT, Behavior Genetics Association Annual Conference, 36th Annual, June 2006. |