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Title: Modeling Age-of-Onset in Behavior Genetic Substance Use Research: It's About Time?
Resulting in 1 citation.
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Bard, David E. |
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Modeling Age-of-Onset in Behavior Genetic Substance Use Research: It's About Time? Presented: Storrs, CT, Behavior Genetics Association 2006 Annual Meeting, June 20-25, 2006 Cohort(s): NLSY79 Publisher: Behavior Genetics Association Keyword(s): Alcohol Use; Behavior; Cigarette Use (see Smoking); Event History; Genetics; Kinship; Modeling, Biometric; Siblings Permission to reprint the abstract has not been received from the publisher. A brief history of age-at-onset modeling in behavior genetics was presented followed by a new discrete-time survival method for estimating ACE variance components of genetically informative age-at-onset data. The new method was framed as an adaptation of the Goldstein, [Pan, Bynner (2004)] multilevel model for event histories. Extensions of the model for multivariate outcomes were also discussed. Using this new technique, univariate and multivariate behavior genetic models of alcohol and cigarette initiation were fit to responses from adolescents of the National Longitudinal Survey of Youth (NLSY). This nationally representative sample produced results consistent with prior behavior genetic research on both substances [e.g., Madden et al (1999) Koopmans et al (1999) Stallings et al (1999)]. Initiation of either substance appeared to be predominantly influenced by the environmental sources of variation, with little to no support for additive genetic influences. Despite this similarity, results supported the investigation of both initiations separately, as substantial ACE unique effects were present in the MV model. Lastly, estimates of shared environmental effects from this study were consistently lower than those present in most previous investigations. This can likely be attributed both to the larger variety of genetic relatedness existing in this kinship, as opposed twin-only, sample, as well as the greater variability in age-at-onset measured initiation, as opposed to status indicators (e.g., used, never used). Pros and cons of this more detailed initiation phenotype were discussed in the context of past, present, and future substance use theory and research. |
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Bibliography Citation
Bard, David E. "Modeling Age-of-Onset in Behavior Genetic Substance Use Research: It's About Time?" Presented: Storrs, CT, Behavior Genetics Association 2006 Annual Meeting, June 20-25, 2006. |